• Potent Anti-Inflammatory Tripeptide – KPV (Lysine-Proline-Valine) is the C-terminal fragment of α-MSH, delivering targeted inflammation control by inhibiting NF-κB and MAPK signaling pathways
• Gut Health & IBD Support – Specifically studied for inflammatory bowel conditions, helps reduce intestinal inflammation, supports epithelial barrier repair, and may benefit colitis symptoms
• Rapid Cellular Penetration – Compact molecular structure allows KPV to cross cell membranes more readily than larger peptides for fast-acting anti-inflammatory effects
• Multi-Route Administration – Available for oral use (gut-targeted), subcutaneous injection (systemic), or topical application (skin inflammation) depending on treatment goals
• Clean Anti-Inflammatory Profile – Isolated anti-inflammatory fragment without the pigmentation, appetite, or hormonal effects of the parent α-MSH molecule
KPV Peptide: Precision Anti-Inflammatory Support
KPV is a therapeutic tripeptide consisting of three amino acids—lysine (K), proline (P), and valine (V)—that represents the active anti-inflammatory tail of alpha-melanocyte stimulating hormone (α-MSH). Through decades of research, scientists have identified this specific sequence as the key driver of α-MSH’s anti-inflammatory properties, without the pigmentation or metabolic effects of the full-length hormone.
KPV works at the molecular level by:
NF-κB Pathway Inhibition: Directly blocks nuclear factor kappa B (NF-κB) nuclear translocation, preventing the activation of inflammatory gene cascription
Cytokine Suppression: Reduces production of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6
Melanocortin Receptor Activation: Binds to MC1R and MC3R melanocortin receptors on immune cells (monocytes, macrophages, dendritic cells) to dampen inflammatory responses
MAPK Pathway Modulation: Inhibits mitogen-activated protein kinase signaling involved in inflammation amplification
Epithelial Barrier Support: Promotes intestinal and skin barrier integrity and repair
TIRZEPATIDE
RETATRUTIDE
SEMAGLUTIDE
CAGRILINTIDE
AOD9604
BPC-157
TB-500
GHK-CU
ELORALINTIDE
KLOW
KPV
CJC-1295
IPAMORELIN
TESAMORELIN
EPITHALON
NAD+
SELANK
PT-141
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