KPV Peptide 5mg/10mg/30mg | Anti-Inflammatory Tripeptide

Research-grade KPV peptide for targeted anti-inflammatory and gut health studies.

99%+ Purity – Janoshik third-party tested (HPLC verified)
Multi-Route Admin – Oral (gut), subcutaneous (systemic), topical (skin)
IBD Specialist – Specifically studied for inflammatory bowel disease research
Fast Cell Penetration – Small tripeptide (342 Da) crosses membranes rapidly
Clean Profile – Anti-inflammatory effects without α-MSH side effects
3 Dosage Options – 5mg, 10mg, 30mg vials | COA included

⚠️ For laboratory research use only. Not for human consumption.

KPV Peptide: Targeted Anti-Inflammatory Tripeptide

KPV (Lys-Pro-Val; sequence: Lysine-Proline-Valine) is a bioactive tripeptide representing the C-terminal fragment of alpha-melanocyte stimulating hormone (α-MSH). This isolated fragment delivers potent anti-inflammatory effects without the pigmentation, appetite, or hormonal effects associated with the full α-MSH molecule.

Why Researchers Choose Our KPV Peptide

✓ 99%+ Purity Guaranteed – Third-party tested by Janoshik Analytical (HPLC verified)
✓ Multi-Route Administration – Oral (gut-targeted), subcutaneous (systemic), topical (skin inflammation)
✓ Gut Health Specialist – Specifically studied for inflammatory bowel disease (IBD) research
✓ Rapid Cell Penetration – Compact structure crosses cell membranes more readily than larger peptides
✓ Clean Anti-Inflammatory Profile – Isolated fragment without α-MSH side effects
✓ Complete Documentation – COA, MSDS, reconstitution protocols included
✓ Multiple Dosage Options – 5mg, 10mg, 30mg vials available

Mechanism of Action

NF-κB Pathway Inhibition

KPV directly blocks nuclear factor kappa B (NF-κB) nuclear translocation, preventing the transcription of pro-inflammatory genes. This mechanism has been documented in multiple cell culture and animal models of inflammation.

MAPK Signaling Suppression

Research demonstrates KPV inhibits mitogen-activated protein kinase (MAPK) signaling pathways involved in inflammation amplification, including ERK, JNK, and p38 MAPK cascades.

Melanocortin Receptor Activation

KPV binds to melanocortin receptors (MC1R, MC3R) on immune cells including monocytes, macrophages, and dendritic cells, dampening inflammatory responses through receptor-mediated signaling.

Cytokine Modulation

Studies show KPV reduces production of key pro-inflammatory cytokines including TNF-α, IL-1β, IL-6, and IL-8, while promoting anti-inflammatory IL-10 expression in certain contexts.

Epithelial Barrier Support

Research indicates KPV promotes intestinal and skin epithelial barrier integrity and repair, supporting the protective barrier function compromised during inflammatory conditions.

Common Research Applications

Inflammatory Bowel Disease (IBD) Research

Ulcerative colitis models
Crohn’s disease research
Intestinal inflammation studies
Colitis symptom investigation
Gut barrier function analysis

Gastrointestinal Research

Intestinal permeability studies (“leaky gut”)
Gut-brain axis research
Microbiome interaction studies
Intestinal wound healing
Digestive inflammation models

Dermatological Research

Skin inflammation studies
Wound healing research
Topical anti-inflammatory applications
Skin barrier function
Dermatitis models

General Inflammation Research

Systemic inflammation models
Immune response modulation
NF-κB pathway studies
Cytokine production research
Inflammatory signaling pathways

Multi-Route Administration Options

🔹 Oral Administration (Gut-Targeted)

Best for: Inflammatory bowel disease research, gut inflammation studies

Direct delivery to intestinal tissue
High local concentration in GI tract
Minimal systemic absorption (localized effect)
Can be administered in solution or capsule form in animal models

💉 Subcutaneous Injection (Systemic)

Best for: Systemic inflammation research, whole-body distribution studies

Predictable bioavailability
Sustained systemic exposure
Standard research peptide administration method
Suitable for long-term treatment protocols

🧴 Topical Application (Skin-Targeted)

Best for: Dermatological research, skin inflammation studies, wound healing

Direct application to affected skin areas
Localized anti-inflammatory effect
Minimal systemic exposure
Can be formulated in creams, gels, or solutions

Product Specifications

Peptide Sequence	Lys-Pro-Val (KPV)
Full Name	Lysine-Proline-Valine
Molecular Formula	C₁₆H₃₀N₄O₄
Molecular Weight	342.43 g/mol
Purity	≥99% (HPLC)
Appearance	White to off-white lyophilized powder
Available Sizes	5mg, 10mg, 30mg per vial
Storage (Powder)	Store at -20°C (stable 2-3 years)
Storage (Reconstituted)	Store at 2-8°C, use within 30 days
Reconstitution	Bacteriostatic water or sterile saline recommended
Solubility	Water, PBS, physiological saline

KPV vs. Other Anti-Inflammatory Peptides

Feature	KPV	BPC-157	TB-500
Primary Target	Inflammation (gut specialist)	Tissue repair (general)	Tissue repair (muscle)
Oral Administration	✓ Highly Effective	✓ Effective	✗ Poor Bioavailability
Cell Penetration Speed	✓ Fast (small size)	Moderate	Moderate
IBD Research Suitability	✓ Specifically Studied	General GI support	Not primary application
Topical Application	✓ Effective	✓ Effective	Limited data
Molecular Size	342 Da (smallest)	~1,419 Da	~4,963 Da

Quality Assurance & Testing

Third-Party Verified: Every batch independently tested by Janoshik Analytical
HPLC Purity Analysis: High-performance liquid chromatography confirms ≥99% purity
Mass Spectrometry: Molecular weight verification ensures correct peptide sequence
Amino Acid Analysis: Confirms precise KPV composition (Lys-Pro-Val)
Sterile Processing: Lyophilized under aseptic GMP conditions
Batch-Specific COA: Certificate of Analysis provided with exact test results for your batch
Endotoxin Testing: LAL assay confirms low endotoxin levels for research applications

Ordering Information & Pricing

Available Sizes:

5mg vial – Ideal for preliminary studies and dosage optimization
10mg vial – Standard research size for extended protocols
30mg vial – Bulk research size for long-term studies (best value)

Bulk Discounts: Tiered pricing available for research institutions and volume orders. Contact us for custom quotes on orders of 10+ vials.

Documentation Provided:

Batch-specific Certificate of Analysis (COA)
Material Safety Data Sheet (MSDS)
Reconstitution protocol guide
Storage and handling recommendations
Administration route guidelines (oral, subcutaneous, topical)

Shipping: Worldwide cold-chain logistics at -20°C with ice packs. In-stock orders ship within 1-3 business days.

⚠️ IMPORTANT – RESEARCH USE ONLY

This product is intended strictly for laboratory research and in-vitro studies only.

Regulatory Status

NOT for human or animal consumption
NOT a dietary supplement, drug, or cosmetic
NOT intended to diagnose, treat, cure, or prevent any disease
NOT FDA approved for therapeutic use

Purchaser Acknowledgment

By purchasing KPV peptide, you confirm that:

✓ You are a qualified researcher or represent a licensed research institution
✓ You understand this product is for laboratory research purposes only
✓ You will NOT use this product for human or animal treatment
✓ You will comply with all applicable laws and regulations in your jurisdiction
✓ You will handle this material according to proper laboratory safety protocols

Safety & Handling

Handle in a properly equipped laboratory environment
Use appropriate personal protective equipment (PPE)
Consult MSDS before use
Store at recommended temperatures to maintain stability
Dispose of according to institutional and local regulations

These statements have not been evaluated by the FDA, EMA, or any other regulatory authority.
This product is not intended to diagnose, treat, cure, or prevent any disease.

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